Endocrine Abstracts

In this study, we attempted to demonstrate the expression of GHSR-1a receptor and possible effects of its activation in human, rat and boar spermatozoa. For demonstration of GHSR-1a immunocytochemical, immunofluorescence and western blotting techniques were applied. The effects of receptor activation was tested in a series of in vitro incubations of spermatozoa with or without addition of ghrelin and the effects were evaluated using confocal microscopy and flow cytometr...

Type 1 iodothyronine deiodinase (D1) is responsible for the conversion of thyroxin (T4) into tri-iodothyronine (T3). The enzyme is mainly present in thyroid, liver and kidneys.There is strong evidence that the metabolism of thyroid hormones is disturbed in some neoplasmatic tissues. However there are only few available data about D1 enzymatic activity in liver tumors.The aim of this study was to estimate the e...

FNH is the second most common benign liver tumor caused mainly by oral contraceptives. D1, which is a crucial enzyme in catalyzing prohormone thyroxine (T4) into active triiodothyronine (T3), is mainly present in such tissues as thyroid, liver and kidney. There are only few data about D1 enzymatic activity in neoplasmatic conditions. Mostly in tumors reduced D1 activity was found.The aim of the study was to examine the activity of t...

Children born with low birth weight (LBW, below 2500 g) exhibit slower development with deficit of height susceptibility to recurrent infections, especially of respiratory tract and, in adulthood, an increased risk of developing syndrome X. One possible explanation could be an enhanced elimination of cells by apoptosis.The aim of this study was evaluate of mechanism of lipid peroxidation and activity of caspase 3 in children with low birth weight.<p ...

Introduction: Hypopituitarism can be caused by a number of different etiologic factors including metastatic cancer. Metastasis to the pituitary gland is rare, accounting for only 1.8% of all metastases, and is often detected incidentally by symptoms associated with hormone dysfunction like hyponatremia. Breast and lung cancer are the primary neoplasms with well established properties of pituitary infiltration. Metastases from gastric cancer are unusual and constitute less than...

Graves’ disease (GD) is hyperthyroidism associated with organ-specific autoimmune 14 inflammation. GD occurs more frequently in adults than in children, however, pediatric patients are 15 a therapeutic challenge due to cycles of remissions and relapses requiring constant monitoring at 16 every stage of treatment administered. Dendritic cells (DCs) are considered a link between innate 17 and adaptive immunity. DCs as antigen-presenting cells (APCs) are involved in antigen ...

Introduction: Alzheimer disease (AD) is the leading cause of dementia. While impaired glucose homeostasis has been shown to increase AD risk and pathological loss of tau function, the latter has been suggested to contribute to the emergence of the glucose homeostasis alterations observed in AD patients. However, the links between tau impairments and glucose homeostasis, remains unclear.Objective: In order to better understand the links between tau and gl...

Introduction: Oncocytic adrenocortical neoplasms (OAN) are very rare tumors and they are usually nonfunctional and benign. Approximately 17% of the adrenal oncocytomas are functional. Their clinical and pathological characteristics are unique. The estimated overall median survival for malignant OANs is more favorable than that of conventional adrenocortical carcinomas.Case report: We present the case of a 79-year-old male who attended consultations for s...

Association between anorexia nerviosa (AN) and low bone mass has been demonstrated. Bone loss associated with AN involve hormonal and nutritional impairments, though their exact contribution is not clearly established. We compare bone mass in AN patients with women of similar weight with no criteria for anorexia nervosa, and a third group of healthy, normal-weight, age-matched women. The study included 48 patients with AN (DSM-IV criteria), 22 healthy eumenorrheic women with l...

Introduction: BCC is a congenital epithelial neck cyst, which occurs due to failure of the second branchial cleft to obliterate during embryogenesis. Development of PTC inside the cyst is extremely rare.Case description: A 29-year-old female presented to the endocrinology clinic with a gradually increasing painless mass in the right lateral region of the neck, identified on ultrasound examination as an anechoic cyst of size 2×2×5 cm with a smoo...